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Winter 2002
This information effective for Winter 2002.
Check with instructor the first day of class for any changes.
Winter 2002
Instructors: David Deamer, Department of Chemistry and Biochemistry and Ellen
Suckiel, Professor, Department of Philosophy
Phone: 459-5158 (David Deamer)
E-mail: deamer@hydrogen.ucsc.edu
and suckiel@ucsc.edu
TTH 4:00–5:45 p.m.
Classroom Unit 1
Estimated enrollment: 150
Course objective:
To introduce students to ethical and social concerns related to recent advances in science and biotechnology.
Course structure:
This course is designed to meet general education requirements, and will serve
both science majors and non-science majors in their junior and senior years.
Significant numbers of graduate students are also expected to participate. The
course will have two instructors—one from the Chemistry/Biochemistry Department
and one from the Philosophy Department, as well as visiting speakers who have
expertise in specific areas of science, business and ethics. The instructors
will introduce the main questions of the course and will be responsible for
leading discussions and evaluating student performance.
A typical week will have a guest speaker on Tuesday, necessarily scheduled in
the late afternoon in order to accommodate travel to the Santa Cruz campus.
The speaker will be asked to teach from his/her background, particularly using
case studies to focus on actual experiences related to the difficult questions
addressed by the course. The one hour talk will be followed by half an hour
discussion, and afterwards groups of 6–8 students will be invited to join
the speaker for dinner. On Thursday, the instructors will lead a discussion
of the points made by the speaker, and all students will be urged to participate
fully in the discussion.
Topical outline by week, winter quarter 2002:
January 3. Introduction to syllabus and goals of course. Details of work required from students, schedule of speakers, library resources. D.W. Deamer/E. Suckiel
Week 1.
January 8. Introduction to ethical questions in research, biotechnology and related business. D.W. Deamer/E. Suckiel
January 10. How is science done, and how is research funded? Universities, government laboratories and industrial research. D. W. Deamer/E. Suckiel
Week 2.
January 15. The pharmaceutical industry and the search for new drugs: Ethical considerations. Frank Szoka, Professor of Pharmocology, UC San Francisco
Week 3.
January 22. Overview of ethical considerations in biomedical research. Dr. Baruch Blumberg, Nobel Laureate 1976, Director of the National Astrobiology Institute, NASA Ames, Moffett Field CA
Week 4.
January 29. The Human Genome.
David Haussler, HHMI Investigator, UC Santa Cruz. “What can we do now that we know the human genome sequence, and what should we do.”
Week 5.
February 5. The ethics of weapons development: Research at the Department of Defense. (Speaker invited)
Week 6.
February 12 . How is science policy set? Government regulatory agencies..
Chancellor MRC Greenwood, UCSC
Week 7.
February 19. The ethics of enhancing the human genome. Dr. Jay Ogilvy, President, General Business Networks, Berkeley CA
Week 8.
February 26. The ethics of research on animal models and human subjects
Brent Constanz, Corazon Inc. Berkeley CA. “Crossing the Chasm: from benchtop to bedside—taking new medical technologies into the clinic.”
Week 9.
March 5. Scientific misconduct. Prof. Robert Hazen, George Mason University, Fairfax VA
Week 10.
March 12. Ethical concerns regarding genetically modified organisms.
Jim Kent, UC Santa Cruz. “Prometheus meets Pandora: Benefits and Risks of Genetically Engineered Food and Organisms.”
The course will be taught for 3 units of credit, which reflects 20 hours in lecture and discussion, weekly assigned reading pertinent to science ethics, and written reports. Some examples of assigned reading follow:
Science Careers—Playing to Win. C. Holden. Science 265:1905–1906, 1994.
Internet site: The Online Ethics Center for Engineering and Science. www.onlineethics.org
Evaluation of student performance.
Students will be required to write nine short weekly papers in which they integrate and analyze the lectures, discussions and course readings. In their papers, students will be asked to demonstrate an understanding of the major scientific and ethical issues involved in each topic. They will be responsible for exploring the technological and social promise, as well as the appropriate moral constraints, on the scientific activities being examined in the course. All written work will be read by the instructors and evaluated for content, clarity, style, and grammatical usage.
Winter 2002
Instructor: Frank Andrews
Office: 317 Thimann
Phone: 459-2776
E-mail: andrews@chemistry
MWF 11:00–12:10 p.m.
Kresge 327
Short Course Description: Macroscopic thermodynamics and chemical kinetics for chemistry and biochemistry students who are expected to understand this material and use it for basic problem-solving, in their careers and their future undergrad and graduate education.
Text: Physical Chemistry, 3rd edition, R. A. Alberty and R. J. Silbey,
John Wiley (chaps 1–8 and 18).
Quizzes and Exams: On every Friday except the first one, we will have either a short, 10-minute quiz at the end of class over the homework due that day, or we will have a midterm exam during the entire class period. For midterms and final (but not for quizzes), you can bring a single 8 1/2 x 11 inch sheet of paper with whatever you want on both sides of it, so long as you have personally done the writing and have not used a xerox machine to reduce the printing in size.
Note: The final exam will be at the time scheduled in the class schedule. If you cannot be in Santa Cruz to take that exam, do not enroll in the course.
Homework: There will be homework assignments due each Friday except the first of the term. The homework is for your benefit; it will not be graded.
Reader: In addition to the text, which by the way will also be the text for Chem 163C, if you are planning to go on, there is a reader which you will want to get. It contains all the homework assignments and the worked-out homework problems, plus a few other things of interest.
Winter 2002
Instructor: Rebecca Braslau
Office: Thimann 337
Phone: 459-3087
TTH 12:00–1:45 p.m.
Stevenson 221
Discussion Section:
Monday nights, 7:00 p.m.
Thimann 339 on January 14, 21 and 28.
This is a 5 week course designed to follow Chemistry 240E (Modern Synthetic Reactions) offered by Professor Singaram. Prerequisite: 240E or consent of instructor
Assignments and Exams: There will be two exams: a midterm worth 100 pts on January 24, and a final exam worth 150 points on February 5. Three sets of homework (15 pts per set) will be assigned during the half quarter, and should be turned into Rebecca’s mailbox by 10:00 a.m. on Monday the day of the discussion section. Attendance at the discussion sections on Monday nights is Mandatory.
No single text will be used, although the following reference books are available
in the library:
March, Advanced Organic Chemistry
Noyori, Asymmetric Catalysis in Organic Synthesis
Ager, Asymmetric Synthetic Methodology
Mulzer, Organic Synthetic Highlights
Fuhrhop & Penzlin, Organic Synthesis: Concepts, Methods and Starting
Materials
Seyden-Penne, Chiral Auxiliaries and Ligands in Asymmetric Synthesis
Morrison, Asymmetric Synthesis Vol. 4 (contains a list of optically active
starting materials)
The following topics will be covered:
Introduction
Literature and References
Starting Materials
Retrosynthetic Analysis
Selectivity
Other 5-Membered Ring Synthesis
Control of Stereochemistry
Relative Diastereoselectivity
Synthetic Strategy
Convergence
Atom Economy
Strategic Bonds
Biomimetic Strategy
Key Reaction Strategy
Formal Synthesis
Computers