Chemistry - Winter 1999

Discussion Sections: Homework is to be turned in and returned at your discussion section. Attendance and participation in your discussion section will be considered in your final evaluation.

Required Materials: John McMurry, "Organic Chemistry," 4th edition, Brooks/Cole Publishing Co.: Pacific Grove, CA, 1996; Susan McMurry, "Study Guide and Solutions Manual for Organic Chemistry," 4th edition, Brooks/Cole Publishing Co.: Pacific Grove, CA, 1996. A molecular model kit (any brand).

E-mail: A current e-mail address is required. Announcements, corrections and assignments will be sent to you by e-mail. You are responsible for anything announced by e-mail just as if it were announced in lecture. There will be a web page at http://www.chemistry.ucsc.edu/teaching/Winter99/Chem108B for the class. Questions on course material can be sent to the Prof. Braslau at braslau@chemistry by e-mail, although I strongly encourage you to come to office hours in person when possible.

Assignments and Exams: A list of assigned problems will be handed out at the beginning of the quarter, to be turned in at the designated dates. Since you will have the solution manual, the problems should be completed and corrected before being turned in for credit. The neatness and correctness of the original answers will not be of concern, rather the completeness in doing the assigned problems will be.

I strongly encourage you to make use of the office hours and discussion sections to discuss problems, exercises or concepts that are not clear. Two 1 3/4 hour exams (100 pts each) will take place on February 2 and March 2, 1999. The Final Exam (200 pts) will be held on Tuesday, March 16 at 12:00 noon - 3:00 pm. If you have documented disability-related accommodation requests, please see me during office hours at least three weeks before each exam. All students should plan to be here for the exams: NO MAKE-UP EXAMS WILL BE ADMINISTERED. Please Note: Cheating on exams will absolutely Not be tolerated. No "warnings" will be given.

Tentative Lecture Schedule

Date Topic Text Chapter

Jan 5 Nuclear Magnetic Resonance Spectroscopy 13

Jan 7 Alcohols and Thiols 17

Jan 12 Alcohols and Thiols, Ethers, Epoxides and Sulfides 17, 18

Jan 14 Ethers, Epoxides and Sulfides, Intro to Carbonyl Chemistry 18, p.705

Jan 19 Aldehydes and Ketones 19

Jan 21 Aldehydes and Ketones, Carboxylic Acids 19, 20

Jan 26 Carboxylic Acid Derivatives 21

Jan 28 Carboxylic Acid Derivatives, Carbonyl Alpha-Substitution Reactions 21,22

Feb 2 First Exam Chapters 13, 17-20

Feb 4 Carbonyl Alpha-Substitution Reactions 22

Feb 9 Carbonyl Condensation Reactions 23

Feb 11 Aliphatic Amines 24

Feb 16 Exchange Day: no lecture for 108B

Feb 18 Arylamines and Phenols 25

Feb 23 Carbohydrates 26

Feb 25 Carbohydrates 26

March 2 Second Exam Chapters 21-25

March 4 Amino Acids, Peptides and Proteins 27

March 9 Amino Acids, Peptides and Proteins 27

March 11 Lipids 28

March 16 Final Exam Tuesday 12:00 noon -3:00 p.m comprehensive

(formerly Chemistry 8M)

Continuation of 108 L, the main emphasis of this class are spectroscopic techniques such as infrared (IR) and nuclear magnetic resonance (NMR) which are the chemist's extended eyes. Students learn to obtain and interpret their own spectra as a routine part of their experimental work. They also gain further insight into gas chromatography, thin layer chromatography, and organic synthesis through extensive practice. Most of the experiments in this class have a direct relation to the bio-sciences, such as the synthesis and analysis of analgesics, analysis of milk and synthesis of thyroid-hormone related compounds.

The second part of the experimental organic chemistry course. The students will learn techniques such as column chromatography,thin layer chromatography, kinetics, IR, and NMR. A challenging class with many applications in the biosciences. The students will gain first hand experience in problem-solving in the laboratory.

Thermodynamics and Kinetic Theory, is a stand-alone course primarily dedicated to thermodynamics. The molecular underpinnings of macroscopic thermodynamics will also be covered, though quantitative applications of statistical mechanics will be covered in Chem 163C in the Spring. The text is Physical Chemistry - A Molecular Approach, by D.A. McQuarrie and J. D. Simon, University Science Books. This is the same text being used for Chem 163A and 163C. Students who are missing a math or physics prerequisite might still be fully qualified to take this course, so they should contact the instructor, Frank Andrews, andrews@chemistry or ext 92776.

Revised 7/23/04.