SPRING 2001

This information effective for Spring 2001.
Check with instructor the first day of class for any changes.

Chemistry

[CHEM-007] [CHEM-080B] [CHEM-146A] [CHEM-240F]

7. Organic Chemistry Survey

Spring 2001
Instructor: Lydia Gregoret

Go to: http://tito.ucsc.edu/chem7/

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80B. Science and Human Values

A Writing-Intensive Lecture Course

Instructor: Frank Andrews, Professor of Chemistry

General Education Codes: T and W

Course Description

A study of the impact of the natural sciences and science-based technology on the values of individuals and social groups and on the quality of human life. This writing-intensive course does not focus on chemistry. Prerequisite: satisfaction of the Subject A requirement. (General Education Codes: T2, W)

Purpose of the Course

Learn the methods of the sciences, their strengths and limitations, and a number of scientific conclusions and theories that historically have impacted human values
Consider the effects of living in a scientific/technological society on your values and those of society
Acquire a structure and language for analyzing values, understand your own values and how you acquired them, choose your values consciously rather than unconsciously, and create a vision of a life well lived
Be able and willing to enter frames of reference of other people who differ from you, exploring what, if anything, makes them seem threatening
Learn to develop positions, articulate them powerfully and peacefully, and live life with passion

Requirements of Students

To attend lectures (MWF) and write the daily quiz at the end of each lecture. This is always the students' 5 to 15 minute response to the question, Based on what happened in lecture today, what do you want to comment on, and comment on it. The professor reads all the quizzes and returns them, sometimes with responses, at the next class.
To attend weekly section meetings and turn in the assigned weekly paper (see below) for the section leader to read and comment on.
To read the essays in the course reader by the dates assigned.
If the student has not turned in enough daily quizzes, to turn in short papers on some of the essays in the reader. The required number of such papers will is determined by the professor for each such student.

The Weekly Writing Assignments for Section Meetings

Free-write: Exploring Your Values and the sources from which you derived them.
Free-write: Exploring Your Higher Values. What makes some of your values higher or lower than others.
First compelling-convincing paper, free-write. Identify a topic about which you feel strongly, and free-write the basis for a paper to convince others to adopt your position.
Write your living will, reflecting your own views of what makes your life worth living, and write it in such a compelling way that the people who read it will actually honor it.
First compelling-convincing paper, final draft. After receiving the feedback on your draft (week 3) from your section leader, write the polished version of this paper.
Free-write on exercises on the power of one's point of view. Approach the "same" object, i.e., a tree of your choice, from a variety of viewpoints. Notice and describe your experiences.
Positive reflection on your life as written by a loved one after your death. By adopting this perspective of looking back on life and the viewpoint of someone who loved us, we can often learn a great deal about what we would like to accomplish while we are alive.
Second compelling-convincing paper. This paper is similar to the first, on a different topic, except we do not have enough time to allow submission of the rough draft to the section leader for comments.
Statement of your primary values and a commitment to living by them. This paper sums up the quarter's self-reflections in a form students can and do come back to over and over in the future.

Brief Outline of Topics Covered

Values:

What are values? Extrinsic vs. intrinsic values.

Subjectivity vs. objectivity, the experience of choosing

Bases for values: External authority, personal experience, emotion, logic, deliberate commitment, intuition

Freedom and responsibility

Values and meta-values

Science:

What is science, the values of science, advantages and limitations

Is science value-free?

How the six bases for values operate in science

Social values that have been fostered by the success of science

Technology:

What is technology; how it has affected human life

Thermodynamics, energy, entropy, forms

Energy use: coal, oil, nuclear, solar, conservation

Greenhouse effect and solar warming

The technological fix, technological imperative, technological arrogance

"Appropriate technology"

Models of Reality and the Scientific Method:

Reality

Meaning

Classical mechanics

Action at a distance

Relativity theory

Particles vs. Waves: light, matter (quantum mechanics)

What can be said about "reality" in science?

Eternalism, nihilism, "is" vs. "as"

Human Beings and the Relationship Between Mind and Body:

Causes, purposes, choices

Fire and phlogiston, heat flow and caloric, light and the ether

The end of vitalism

Evolution, natural selection

Competition or cooperation

Individual or group

Origin of life

Survival of the "fittest," the naturalistic fallacy, social Darwinism

Sociobiology and "selfish genes"

Biological determinism vs. biological constraints

Psychology and Behaviorism:

Classical conditioning, operant conditioning

The mind-body problem

Death and evolution

"Who am I?" Self-image

Social traps, e.g., "the prisoner's dilemma"

How to get out of or avoid social traps

Decision theory vs. learning theory

Decisions based on computers

Ethics and Values:

Ethics: the concern of the individual with others: society, nature, and the future

Society as a common value

Incommensurate values

Right/wrong, good/bad

Should, must, and ought

Blame, shame, and guilt

Ethical relativism vs. ethical absolutism

Bottom-line values, fanaticism

Exponential Growth, World Population:

Technology and world population

Compound interest, capitalism, the discounting of future wealth

What actually lowers birth rates?

Challenges of Living:

Loving/caring/serving/making a difference

Purpose, goals, mindfulness, responsibility

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146A. Advanced Laboratory in Organic Chemistry (2 credits)

Spring Quarter 2001
Tuesday, Thursday 1:00 P.M. - 5:00 P.M., Thimann 249

Instructor: Rebecca Braslau (braslau@chemistry.ucsc.edu)
Office: Thimann 337, phone: 459-3087
Office Hours: Tentatively 1:30 - 2:30 Wednesdays

Teaching Assistant: Tentatively Aaron Nilsen (nilsen@chemistry.ucsc.edu)
Office: Thimann 331, phone: 459-4525
Office Hours: TBA

Prerequisite: successful completion of the Chemistry 108 (A,B, L, and M) series or Chemistry 112 (A,B,C,L,M, and N) series or consent of instructor

Required Assignments: There will be several written assignments to be done in a professional, complete manner. More details will be made available in class.

Tentative Schedule:

1. Qualitative Organic Analysis: a Two-Day Experiment

A number of standard qualitative tests indicative of specific organic functional groups will be carried out on a series of known compounds. In this portion of the experiment, students will work in pairs. Following this, each student will work independently to identify two unknowns following a flowchart utilizing these qualitative tests. The lab report will consist of a record of the results of the qualitative tests on the unknowns, identification of the unknowns, and a clear mechanistic discussion of how each of the 12 qualitative tests work.
Due in class April 10, 2001 (one week after completion of the experiment!)

2. Identification of Three Unknowns

Each student will be given a unique mixture of three organic unknowns, which will be separated by standard laboratory procedures. After purification, each of the clean compounds will then be subjected to a variety of spectroscopic analyses (IR, ¹H and ¹³C-NMR, etc.) outlined in class. The student should use this information to successfully identify each of them. The lab report will consist of a record of the separation and purification schemes and yields obtained for each step, the fully assigned and interpreted spectra, and a discussion of the structural analysis.
Due June 4, 2001: Absolutely no reports will be accepted late!

3. Laboratory Notebook

An up-to-date, current laboratory notebook should be kept while doing experiments. The notebook will be checked periodically by the instructor or the T.A., and will be turned in on June 4 with the final assignment.

Grading:

Qualitative Analysis, 100 pts

Identification of Three Unknowns, 300 pts

Technical Skill/Lab Notebook (as evaluated by the instructor and TA), 100 pts

Note: all assignments must be completed on time to pass the course!

No Make-up Laboratory Sessions will be arranged!

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240F. Selectivity and Strategy in Organic Synthesis

First 5 Weeks of Spring Quarter 2001

Tuesday, Thursday 10:00 A.M. - 11:45 A.M.

Instructor: Rebecca Braslau (braslau@chemistry.ucsc.edu)
Office: Thimann 337, phone: 459-3087

Discussion Section: Tentative Dates: Monday nights, 7:00 P.M.. Thimann 339: April 9, 16, and 23

This is a 5-week course designed to follow Chemistry 240E (Modern Synthetic Reactions) offered by Professor Singaram. Prerequisite: 240E or consent of instructor

Assignments and Exams: There will be two exams: a midterm worth 100 pts on April 17, and a final exam worth 150 points on April 26. Three sets of homework (15 pts per set) will be assigned during the half quarter, and should be turned into Rebecca's mailbox by 10:00 A.M. on Monday the day of the discussion section. Attendance at the discussion section Monday nights is mandatory.

No single text will be used, although the following reference books are available in the library:

March, Advanced Organic Chemistry; Noyori, Asymmetric Catalysis in Organic Synthesis; Ager, Asymmetric Synthetic Methodology; Mulzer, Organic Synthetic Highlights; Fuhrhop & Penzlin, Organic Synthesis: Concepts, Methods, and Starting Materials; Seyden-Penne, Chiral auxiliaries and ligands in asymmetric synthesis; Morrison, Asymmetric synthesis, Vol. 4 (contains a list of optically active starting materials)
The following topics will be covered:

Introduction

Literature and References

Starting Materials

Retrosynthetic Analysis

Selectivity

Control of Stereochemistry

Relative Diastereoselectivity

Ring Systems
Acyclic Stereocontrol

Felkin-Ahn, Cram Chelation Control

Aldol Stereochemistry

Allylation of Carbonyls

Reconnective Strategy

Absolute Stereochemistry

Relative Diastereoselectivity using Optically Pure Materials

Chirons

Classic Resolution

Chiral Auxiliaries

Enantioselectivity

Stoichiometric Asymmetric Induction

Kinetic Resolution

Catalytic Asymmetric Induction

Asymmetric Amplification

Selected Reactions and Processes

Cyclizations

Baldwin's Rules

Thorpe-Ingold Effect

Cationic, Anionic, Radical & Organometallic Cyclizations

Other 5-Membered Ring Synthesis

Pauson-Khand

Carbonyl Condensations

Nazarov Cyclization

Palladium TMM

[3 + 2] Dipolar Cycloadditions

Synthetic Strategy

Convergence

Atom Economy

Strategic Bonds

Biomimetic Strategy

Key Reaction Strategy

Formal Synthesis

Computers

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