Biology - Spring 1999

Time: Tu, Th 10:00-11:45am

Course Instructors:

Dr. Yishi Jin
E-Mail: jin@biology.ucsc.edu

Dr. Lindsay Hinck
E-Mail: hinck@biology.ucsc.edu


Course description:

This course is dedicated to provide rigorous, first-hand knowledge on neural development. It emphasizes on comparative studies in both invertebrate and vertebrate nervous systems. Topics include neurogenesis, neuronal fate determination, neuronal migration, axonal guidance and synaptogenesis. One lecture will be given on each topic to introduce the basic concepts and background information, which is followed by one discussion section on chosen research papers. Students will receive one-on-one instruction before giving presentations. Students are expected to participate actively in lectures and discussions. Term paper--an essay on a selected topic.
Enrollment is limited. Undergraduate enroll by interview only.
 
Preliminary course reading list:
neural induction in vertebrates

Review articles:
 
1. Hemmati-Brivanlou, A. and Melton, D. "Vertebrate neural induction". Annu. Rev. Neurosci. 1997, 20: 43-60.
 
2. Roelink, H. "Tripartite signaling of pattern: interactions between hedgehogs, BMPs and Wnts in the control of vertebrates development." Current Opinion in Neurobiology, 1996, 6, 33-40.
 
Research papers:
1. Zimmerman LB; De Jesus-Escobar JM; Harland RM.
"The Spemann organizer signal noggin binds and inactivates bone morphogenetic protein 4." Cell, 1996 Aug 23, 86(4):599-606.
2. Liem, KFJ., Tremml, G., Roelink, H., Jessell, T.M. "Dorsal differentiation of neural plate cells induced by BMP-mediated signals from epidermal ectoderm" Cell, 1995, 82 969-979.
 
Neurogenesis in Drosophila
Review articles:
 
1. Campos-Ortega JA.
"Genetic mechanisms of early neurogenesis in Drosophila melanogaster."
Molecular Neurobiology, 1995 Apr-Jun, 10(2-3):75-89.
 
2. Jan YN; Jan LY.
"HLH proteins, fly neurogenesis, and vertebrate myogenesis."
Cell, 1993 Dec 3, 75(5):827-30.
 
Research Papers:
 
1. Jarman AP; Brand M; Jan LY; Jan YN.
"The regulation and function of the helix-loop-helix gene, asense, in
Drosophila neural precursors"
Development, 1993 Sep, 119(1):19-29.
 
2. Jennings B; Preiss A; Delidakis C; Bray S.
"The Notch signalling pathway is required for Enhancer of split bHLH
protein expression during neurogenesis in the Drosophila embryo".
Development, 1994 Dec, 120(12):3537-48.
 
Neuronal fate determination: lineage and genetic study
 
Review articles:
1. Jan YN; Jan LY.
"Neuronal cell fate specification in Drosophila."
Current Opinion in Neurobiology, 1994 Feb, 4(1):8-13
 
2. Doe CQ; Technau GM.
"Identification and cell lineage of individual neural precursors in the
Drosophila CNS."
Trends in Neurosciences, 1993 Dec, 16(12):510-4.
 
Research Papers:
 
1. Spana EP; Kopczynski C; Goodman CS; Doe CQ.
"Asymmetric localization of numb autonomously determines sibling neuron
identity in the Drosophila CNS."
Development, 1995 Nov, 121(11):3489-94.
 
2. Spana EP; Doe CQ.
"Numb antagonizes Notch signaling to specify sibling neuron cell fates."
Neuron, 1996 Jul, 17(1):21-6
 
 
Neural fate determination in vertebrates
 
Review articles:
 
1. Ruiz i Altaba A; Jessell TM.
"Midline cells and the organization of the vertebrate neuraxis."
Current Opinion in Genetics and Development, 1993 Aug, 3(4):633-40.
 
2. Tanabe,Y., Jessell,T.M.
"Diversity and pattern in the developing spinal cord"
Science 1996 274: 1115-1123
 
Research Papers:
 
1. Yamada T; Pfaff SL; Edlund T; Jessell TM.
Control of cell pattern in the neural tube: motor neuron induction by
diffusible factors from notochord and floor plate.
Cell, 1993 May 21, 73(4):673-86.
 
2. Tsuchida T; Ensini M; Morton SB; Baldassare M; Edlund T; Jessell TM; Pfaff
SL.
" Topographic organization of embryonic motor neurons defined by expression
of LIM homeobox genes"
Cell, 1994 Dec 16, 79(6):957-70.
 
 
Neuronal migration
Review articles:
 
1. McConnell SK.
"Strategies for the generation of neuronal diversity in the developing
central nervous system."
Journal of Neuroscience, 1995 Nov, 15(11):6987-98.
 
2. Hatten ME.
"The role of migration in central nervous system neuronal development."
Current Opinion in Neurobiology, 1993 Feb, 3(1):38-44.
 
Research Paper:
 
1. Rivas RJ; Hatten ME.
"Motility and cytoskeletal organization of migrating cerebellar granule
neurons."
Journal of Neuroscience, 1995 Feb, 15(2):981-9.
 
 
2. Chenn A; McConnell SK.
"Cleavage orientation and the asymmetric inheritance of Notch1
immunoreactivity in mammalian neurogenesis."
Cell, 1995 Aug 25, 82(4):631-41.
 
axonal guidance--genetics
 
Review:
1. Goodman, C.S.
"Mechanisms and moleculares that control growth cone guidance"
Annu. Rev. Neurosci. 1996 19: 341-377
 
2. Culotti JG; Kolodkin AL.
Functions of netrins and semaphorins in axon guidance.
Current Opinion in Neurobiology, 1996 Feb, 6(1):81-8.
 
 
Research Papers:
 
1. Hedgecock EM;Culotti JG;Hall DH
"The unc-5, unc-6, and unc-40 genes guide circumferential migrations of pioneer axons and mesodermal cells on the epidermis in C. elegans."
Neuron 2: 61-85 1990
 
 
2. Seeger M; Tear G; Ferres-Marco D; Goodman CS.
"Mutations affecting growth cone guidance in Drosophila: genes necessary
for guidance toward or away from the midline."
Neuron, 1993 Mar, 10(3):409-26.
 
 
axonal guidance--collapsin
 
Review articles:
1. Dodd,J., Schuchardt,A.
"Axon guidance: a compelling case for repelling growth cones"
Cell 1995 81:471-474
 
2. Tessier-Lavigne,M., Goodman,C.S.
"The molecular biology of axon guidance"
Science 1996 274: 1123-1133
 
 
Reseach Papers:
 
1. Luo Y; Raible D; Raper JA.
" Collapsin: a protein in brain that induces the collapse and paralysis of
neuronal growth cones."
Cell, 1993 Oct 22, 75(2):217-27.
 
2. Fan J; Raper JA.
"Localized collapsing cues can steer growth cones without inducing their
full collapse."
Neuron, 1995 Feb, 14(2):263-74.
 
 
axonal guidance--netrin
 
Review articles:
 
1. Goodman CS.
The likeness of being: phylogenetically conserved molecular mechanisms of
growth cone guidance.
Cell, 1994 Aug 12, 78(3):353-6.
 
2. Tessier-Lavigne,M., Goodman,C.S.
"The molecular biology of axon guidance"
Science 1996 274: 1123-1133
 
 
Research Papers:
 
1. Serafini T; Kennedy TE; Galko MJ; Mirzayan C; Jessell TM; Tessier-Lavigne M.
"The netrins define a family of axon outgrowth-promoting proteins
homologous to C. elegans UNC-6."
Cell, 1994 Aug 12, 78(3):409-24.
 
2. Serafini T; Colamarino SA; Leonardo ED; Wang H; Beddington R; Skarnes WC;
Tessier-Lavigne M.
Netrin-1 is required for commissural axon guidance in the developing
vertebrate nervous system.
Cell, 1996 Dec 13, 87(6):1001-14.
 
 
Synaptogenesis:
 
Reviews articles:
 
 
1. Ruegg MA.
"Agrin, laminin beta 2 (s-laminin) and ARIA: their role in neuromuscular
development."
Current Opinion in Neurobiology, 1996 Feb, 6(1):97-103.
 
2. Donoghue MJ; Sanes JR.
"All muscles are not created equal."
Trends in Genetics, 1994 Nov, 10(11):396-401.
 
 
Research papers:
1. Gautam M; Noakes PG; Moscoso L; Rupp F; Scheller RH; Merlie JP; Sanes JR.
"Defective neuromuscular synaptogenesis in agrin-deficient mutant mice."
Cell, 1996 May 17, 85(4):525-35.
 
2. DeChiara, T,M, et al.
"The receptor tyrosine kinase MuSK is required for neuromuscular junction formation in vivo."
Cell, 1996 85: 501-512
 

Revised 7/29/04.