FALL 2001

This information effective for Fall 2001.
Check with instructor the first day of class for any changes.

---

Chemistry

[CHEM-246H]

---

246H. Organic Free Radical Chemistry

Fall 2001
Lecture Times: TTh 12:00-1:45 pm
Instructor: Dr. Rebecca Braslau
(braslau@chemistry.ucsc.edu)
Office: Thimann 337, tel. 459-3087

Prerequisite: successful completion of Chem 143, or Chem 240E or Chem 240F, or consent of instructor

Tentative Course Schedule:

Week 1	Thermodynamics of Organic Free Radicals: Radical Stabilization, Bond Dissociation Energies, Resonance and Electronic Stabilization
Week 2	Kinetics of Organic Free Radicals: Rate Constants of Radical Processes, "Radical Clocks," Persistent Radicals
Week 3	Methods for the Generation of Free Radicals: Thermal, Photochemical, Redox
Week 4	Free Radical Chain Reactions: Tin Hydride Based Methodologies
Week 5	Free Radical Chain Reactions: The Barton Method, and Atom Transfer
Week 6	Stochiometric Free Radical Reactions: SmI2 and other Metal Based Reactions
Week 7	Control of Stereochemistry in Free Radical Reactions
Week 8	Radical Reactions in the Synthesis of Complex Targets, Tandem Reactions
Week 9	Persistent Free Radicals, Controlled Polymerizations
Week 10	Free Radicals in Biology: Amino Acid Radicals, Bergman Diradicals, Radical Damage to DNA, etc.

There will be no single text for the class: the bulk of the material covered will come from the scientific literature (including review articles). In addition, the following texts will be utilized:

• M. J. Perkins, Radical Chemistry, Ellis, Horwood, New York, 1994.
• B. Giese, Radicals in Organic Synthesis: Formation of Carbon-Carbon Bonds, Pergamon, Oxford, 1986.
• D. P. Curran, N. A. Porter, B. Giese, Stereochemistry of Radical Reactions, VCH, Weinheim, 1996.

Student performance will be evaluated by a Midterm, a Final Exam, and a special projects paper.